The COMT gene makes an enzyme that regulates neurotransmitters and hormones. It plays a big role in how your body breaks down estrogen and uses other compounds. If you have a COMT SNP, your body may not process dopamine, norepinephrine, or epinephrine optimally. These vital brain messengers help you cope with stress, chaos, and challenges.

The COMT gene can function too fast or too slow. If your COMT is too fast, you clear neurotransmitters and other compounds too quickly. You may struggle with energy or focus. Sometimes this happens when you have too much of something in the body from other dirty genes. Fast COMT could mean you have excess SAMe or homocysteine. It may also mean you have MTHFR mutations or you don’t have enough folate, B12, other B vitamins, or magnesium.

To support your fast COMT gene, you need supplementation that promotes the optimal way your gene should function. Hydrox-Adeno B12 and Folinic Acid Lozenges provide bioavailable sources of vitamin B12 and folate in methyl-free versions, which might be easier to tolerate if you have a sensitive brain.

Explore other supportive nutrients for healthy COMT activity below, like Optimal Magnesium, Adrenal Support, or Optimal Sleep II.